Russell H Knutsen Selected Research

Williams Syndrome (Williams-Beuren Syndrome)

6/2022	Airflow Obstruction in Adults with Williams Syndrome and Mice with Elastin Insufficiency.
1/2022	Elastin Insufficiency Confers Proximal and Distal Pulmonary Vasculopathy in Mice, Partially Remedied by the KATP Channel Opener Minoxidil: Considerations and Cautions for the Treatment of People With Williams-Beuren Syndrome.
1/2021	Inhibition of NOX1 Mitigates Blood Pressure Increases in Elastin Insufficiency.
1/2018	Minoxidil improves vascular compliance, restores cerebral blood flow, and alters extracellular matrix gene expression in a model of chronic vascular stiffness.
9/2015	Chronic antihypertensive treatment improves pulse pressure but not large artery mechanics in a mouse model of congenital vascular stiffness.
9/2014	Skin findings in Williams syndrome.
1/2014	Williams syndrome predisposes to vascular stiffness modified by antihypertensive use and copy number changes in NCF1.
12/2011	Genetic modifiers of cardiovascular phenotype caused by elastin haploinsufficiency act by extrinsic noncomplementation.

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Russell H Knutsen Research Topics

Disease

16	Hypertension (High Blood Pressure) 01/2021 - 02/2003
9	Supravalvular Aortic Stenosis (Aortic Supravalvular Stenosis) 01/2020 - 11/2003
8	Williams Syndrome (Williams-Beuren Syndrome) 06/2022 - 12/2011
3	Emphysema 06/2022 - 03/2007
3	Cutis Laxa 06/2012 - 08/2007
3	Hypoxia (Hypoxemia) 11/2008 - 09/2005
2	Pathologic Constriction (Stenosis) 09/2014 - 01/2014
2	Autosomal Dominant Cutis Laxa 06/2012 - 09/2010
2	Vascular Remodeling 11/2008 - 02/2008
2	Hyperglycemia 02/2007 - 08/2003
2	Hyperinsulinism (Hyperinsulinemia) 02/2007 - 08/2003
2	Insulin Resistance 02/2007 - 08/2003
1	Chronic Obstructive Pulmonary Disease (COPD) 06/2022
1	Vascular Malformations 01/2021
1	Diabetic Nephropathies (Diabetic Nephropathy) 01/2016
1	Albuminuria 01/2016
1	Kidney Diseases (Kidney Disease) 01/2016
1	Hereditary Nephritis (Alport Syndrome) 01/2016
1	Wounds and Injuries (Trauma) 01/2016
1	Hypertriglyceridemia 01/2016
1	Dyslipidemias (Dyslipidemia) 01/2016
1	Mucopolysaccharidosis VII (Sly Syndrome) 12/2011
1	Inborn Genetic Diseases (Disease, Hereditary) 07/2011
1	Aortic Aneurysm (Aneurysm, Aortic) 09/2010
1	Marfan Syndrome (Marfan's Syndrome) 12/2009
1	Pulmonary Arterial Hypertension 11/2008
1	Right Ventricular Hypertrophy 11/2008
1	Disease Susceptibility (Diathesis) 09/2008
1	Body Weight (Weight, Body) 09/2008
1	Hemorrhage 09/2008
1	Obesity 09/2008
1	Lysosomal Storage Diseases (Lysosomal Storage Disease) 07/2008
1	Mucopolysaccharidosis I (Hurler Syndrome) 07/2008
1	Cardiovascular Diseases (Cardiovascular Disease) 07/2008
1	Aortic Diseases 07/2008
1	Hypertrophy 02/2008
1	Lung Injury 03/2007
1	Pulmonary Hypertension 09/2005
1	Atherosclerosis 05/2005
1	Vascular Diseases (Vascular Disease) 05/2005
1	Essential Hypertension 11/2003

Drug/Important Bio-Agent (IBA)

23	ElastinIBA 06/2022 - 11/2003
6	Proteins (Proteins, Gene)FDA Link 09/2014 - 11/2003
2	EnzymesIBA 12/2011 - 02/2007
2	Dexamethasone (Maxidex)FDA LinkGeneric 02/2007 - 08/2003
2	GlucocorticoidsIBA 02/2007 - 08/2003
2	PPAR alphaIBA 02/2007 - 08/2003
2	Vasoconstrictor AgentsIBA 04/2003 - 02/2003
1	KATP ChannelsIBA 01/2022
1	Minoxidil (Rogaine)FDA LinkGeneric 01/2022
1	SilicatesIBA 01/2021
1	Silicone Elastomers (SE 30)IBA 01/2021
1	PolymersIBA 01/2021
1	AlbuminsIBA 01/2016
1	Serum AlbuminIBA 01/2016
1	Triglycerides (Triacylglycerol)IBA 01/2016
1	Collagen Type IV (Type IV Collagen)IBA 01/2016
1	Antihypertensive Agents (Antihypertensives)IBA 01/2014
1	Biological ProductsIBA 06/2012
1	GlycosaminoglycansIBA 12/2011
1	GlucuronidaseIBA 12/2011
1	TropoelastinIBA 09/2010
1	Fibrillin-1IBA 12/2009
1	microfibrillar proteinIBA 09/2008
1	cathepsin SIBA 07/2008
1	Pancreatic Elastase (Elastase)IBA 07/2008
1	Messenger RNA (mRNA)IBA 07/2008
1	Iduronidase (alpha-L-Iduronidase)IBA 07/2008
1	CollagenIBA 02/2008
1	SmokeIBA 03/2007
1	PhosphoenolpyruvateIBA 02/2007
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 09/2005
1	Oxygen (Dioxygen)IBA 09/2005
1	CholesterolIBA 05/2005
1	LDL CholesterolIBA 05/2005
1	Doxycycline (Periostat)FDA LinkGeneric 05/2005
1	LDL Receptors (LDL Receptor)IBA 08/2003
1	GTP-Binding Proteins (G-Protein)IBA 02/2003

Therapy/Procedure

1	Intravenous Injections 07/2008
1	Surgical Instruments (Clip) 07/2007
1	Vagotomy 02/2007